Thursday 25 July 2013

Rare Condition: The Walking Dead



There are indeed certain things that beat the imagination. There are people who go through terrible sufferings and sometimes wish they were dead. That’s explainable. But a situation where one thinks and strongly believes that he is dead beats the imagination.
Imagine waking up to discover you were dead. A man identified as Graham suffering from a rare condition that caused him to think he was dead has spoken about the experience to NewScientist magazine.
The rare condition known as Cotard’s Syndrome, Cotard Delusion or Walking Corpse Syndrome is a mental disorder in which people hold a delusional belief that they are dead, do not exist, are putrefying, or have lost their blood or internal organs. In rare instances, it can include delusions of immortality.

Some Reported Cases

 In 1788, Charles Bonnet reported one of the earliest recorded cases of Cotard’s Delusion. An elderly woman was preparing a meal when she felt a draft and then became paralyzed on one side of her body. When feeling, movement, and the ability to speak came back to her, she told her daughters to dress her in a shroud and place her in a coffin. For days she continued to demand that her daughters, friends, and maid treat her like she was dead. They finally gave in, putting her in a shroud and laying her out so they could “mourn” her. Even at the “wake,” the lady continued to fuss with her shroud and complain about its color.
Some 100 years later, French neurologist Jules Cotard saw a patient with an unusual complaint. Mademoiselle X, as Cotard called her in his notes, claimed to have “no brain, no nerves, no chest, no stomach and no intestines.” Despite this predicament, she also believed that she “was eternal and would live forever.” Since she was immortal, and didn’t have any innards anyway, she didn’t see a need to eat, and soon died of starvation. Cotard’s description of the woman’s condition spread widely and was very influential, and the disorder was eventually named after him.
In Graham’s case mentioned above, he felt like his “brain didn't exist anymore.” He insisted that the tablets administered by the doctors weren't going to do any good because he didn't have a brain. “I'd fried it in the bath”, he said. The feeling prompted him on occasion to visit the local graveyard. "I just felt I might as well stay there. It was the closest I could get to death. The police would come and get me, though, and take me back home”, he said

Symptoms

The central symptom in Cotard's syndrome is the delusion of negation. Those who suffer from this illness often deny that they exist or that a certain portion of their body exists. Cotard's syndrome has been found to have three distinct stages. In the first stage referred to as Germination, patients exhibit psychotic depression and hypochondriacal symptoms. The second stage called Blooming is characterized by the full blown development of the syndrome and the delusions of negation. The third and Chronic stage is characterized by severe delusions and chronic depression.
People with the Cotard Delusion often become withdrawn from others and they tend to neglect their own hygiene and well-being. The delusion makes it impossible for patients to make sense of reality, which results in an extremely distorted view of the world.
Neurologist took a peek into the brain of Graham mentioned above, monitored metabolism across his brain and found some explanation. It was discovered that metabolic activity across large areas of the frontal and parietal brain regions was so low that it resembled that of someone in a vegetative state.

Treatment

There are several reports of successful pharmacological treatment. Monotherapeutic and combination strategies are both reported. Antidepressants, antipsychotics and mood stabilizers are used. Many report positive effect with electroconvulsive therapy, mostly in combination with pharmacotherapy


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